Acute changes in concentrations of apolipoproteins A-I, B, C-II and lipoprotein(a) in serum covering the period from directly before to 48 hours after chronic haemodialysis.

This study reports the changes in total cholesterol, triacylglycerols, apolipoproteins A-I, B, C-II and (a) before, directly after and 48 hours after chronic renal dialysis on 46 non-selected patients (20 male, 26 female; time since first dialysis 1-203 months (median 22 months), median age 52 years, range 25-82 years). Thirty six of the 46 patients (17 men and 19 women) suffered from hypertension. There were no sex-linked differences in any analyte except cholesterol, which was significantly higher in women than in men at all times. The apolipoproteins were determined with immunoluminometric assays. Apolipoprotein C-II was determined as the apolipoprotein C-II: apolipoprotein B complex. Lipoprotein(a) was determined using two antibodies directed against apolipoprotein(a). Significant increases (p < 0.05) in serum concentrations before and after dialysis were seen for all analytes with the exception of cholesterol (no significant change) and apolipoprotein C-II (significant decrease). The median increases were: cholesterol 5%, triacylglycerols 28%, apolipoprotein A-I 19%, apolipoprotein B 11%, apolipoprotein C-II -39%, lipoprotein(a) [all patients 21%, <300 mg/l 8%, > 300 mg/l 163%]. The values 48 hours after dialysis were not significantly different from the value before dialysis for cholesterol (-5%), apolipoprotein B (0%) and lipoprotein(a) (-2% - all patients). Statistically significant lower concentrations of apolipoprotein C-II (-28%) (p < 0.01) and triacylglycerols (-19%) (p < 0.01) were observed, but not investigated further. The behaviour of lipoprotein(a) was not correlated with any of the other analytes except triacylglycerols, where a statistically significant negative correlation was seen in all groups.(ABSTRACT TRUNCATED AT 250 WORDS)